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Biochemical Evaluation Of The Milk Transfer Of A Single Oral Dose Of
Chlorpyrifos-Methyl In Pregnant Rats
Z.H. Zidan(1) A.E. Bayoumi(1) E.N.
EL-Khatib(2) and M. Reem Ziada(2)
(1)Department of Plant Protection, Faculty of Agriculture,
Ain-Shams University, Shubra El- Kheima, Cairo, Egypt
E-mail: zidan42@hotmail.com
(2)Central
Agriculture Pesticides Laboratory (CAPL), Dokki, Giza, Egypt
Abstract
The lactation (milk) transfer of certain pesticides in female rats were
studied. The pesticides tested included chlorpyrifos-methyl and methomyl as
representative insecticides to the organophosphorus and carbamates chemical
groups, respectively. The milk transfer of the compounds selected were studied
thorough their effects on certain biomarkers such as acetylcholinesterase, total
glutathione content, glutathione S-transferase and ATP-ase in various organs of
the dams after delivery and their corresponding suckling pups. To perform such
study single oral dose of 1/10 and 1/30 of LD50 of the pesticides tested were
administered on the third day after delivery. Rats and pups were killed after 3,
6, 12, 24, and 48 hr. Results obtained indicated that the two compounds were
transferred through lactation route and produced a significant decrease in the
AChE activity of brain and serum of dams and their corresponding pups brain AChE
activity was time and dose-dependent. Also, the data showed a significant
increase in liver total glutathione content. The two doses of
chlorpyrifos-methyl and methomyl tested caused a significant decrease in the
liver GSH content at 12 hr after lactated mothers treatment with 1/10 of LD50 of
chlorpyrifos-methyl, but the lower dose level produced an alteration effect in
relation to time after treatment. Pups liver GSH data showed a significant
decrease after 3 hr of their corresponding lactated mothers' treatment with
1/10 and 1/30 of chlorpyrifos-methyl and methomyl LD50. In case of glutathione
S-transferases, lactated mothers treatment showed a significant increase in the
liver GST activity while serum GST activity was decreased. ATPases, were not
affected significantly by the treatments mentioned.
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