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Histopathological Effects Of Lactation Transfer Of Certain Insecticides In
Rats
E.N. EL-Khatib(1) Z.H. Zidan(2) A.E.
Bayoumi(2) M. Reem Ziada(1) and Eman M. Abd
El-Mottaleb(3)
(1)Central Agriculture Pesticides
Laboratory (CAPL), Dokki, Giza. Egypt
(2)Department of Plant
Protection, Faculty of Agriculture, Ain-Shams University, Shubra El-Kheima,
Cairo, Egypt
E-mail: zidan42@hotmail.com
(3)Animal
Health Research Institute, Dokki, Giza. Egypt
Abstract
The present work was planned to illustrate the histopathological consequences
of most essential body organs of pregnant female rats after delivery (liver,
spleen and kidney) as a result of exposure to organophosphorus compounds
represented by chlorpyrifos-methyl, and carbamate compounds represented by
methomyl,, by applying two dose levels (1/10 and 1/30 of LD50) and sacrificed
within 3, 6, 12, 24, 36 and 48 hours after administration of a single oral dose.
The histopathological studies revealed that the cytotoxic effects of methomyl on
the organs examined was more intensive than chlorpyrifos- methyl and the highest
dose of each insecticide caused the most toxic effect. Also, the cytotoxic
effects of each dose of the two tested insecticides increased with time increase
after administration. The severity of the lesions was more intensive in 1/10
LD50 than that observed in 1/30 LD50 dose level. On the other hand, the severity
of lesions were more extensive and strongly related to the duration of the
exposed pesticides in each dose level.
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